Ben Creisler
Some non-dino papers:
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Significance
Although oral venom systems are ecologically important characters, how they originated is still unclear. In this study, we show that oral venom systems likely originated from a gene regulatory network conserved across amniotes. This network, which we term the "metavenom network," comprises over 3,000 housekeeping genes coexpressed with venom and play a role in protein folding and modification. Comparative transcriptomics revealed that the network is conserved between venom glands of snakes and salivary glands of mammals. This suggests that while these tissues have evolved different functions, they share a common regulatory core, that persisted since their common ancestor. We propose several evolutionary mechanisms that can utilize this common regulatory core to give rise to venomous animals from their nonvenomous ancestors.
Abstract
Oral venom systems evolved multiple times in numerous vertebrates enabling the exploitation of unique predatory niches. Yet how and when they evolved remains poorly understood. Up to now, most research on venom evolution has focused strictly on the toxins. However, using toxins present in modern day animals to trace the origin of the venom system is difficult, since they tend to evolve rapidly, show complex patterns of _expression_, and were incorporated into the venom arsenal relatively recently. Here we focus on gene regulatory networks associated with the production of toxins in snakes, rather than the toxins themselves. We found that overall venom gland gene _expression_ was surprisingly well conserved when compared to salivary glands of other amniotes. We characterized the "metavenom network," a network of â3,000 nonsecreted housekeeping genes that are strongly coexpressed with the toxins, and are primarily involved in protein folding and modification. Conserved across amniotes, this network was coopted for venom evolution by exaptation of existing members and the recruitment of new toxin genes. For instance, starting from this common molecular foundation, Heloderma lizards, shrews, and solenodon, evolved venoms in parallel by overexpression of kallikreins, which were common in ancestral saliva and induce vasodilation when injected, causing circulatory shock. Derived venoms, such as those of snakes, incorporated novel toxins, though still rely on hypotension for prey immobilization. These similarities suggest repeated cooption of shared molecular machinery for the evolution of oral venom in mammals and reptiles, blurring the line between truly venomous animals and their ancestors.
News:
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The known fossil record of crocodyliforms in Europe during the Paleogene is significantly biased, in that the fauna of Western Europe is far better sampled and understood compared to that of Eastern Europe. We describe in detail all known crocodyliform remains from the middle Eocene (Lutetian) Ikovo locality in Ukraine. We conclude that at least two taxa were present: a moderate to large-sized Tomistominae indet. similar to the basalmost known tomistomines, and the small-sized basal alligatoroid cf. Diplocynodon sp. Despite its scarcity, this is the first basal alligatoroid material reported from Eastern Europe (as part of post-Soviet countries) and the easternmost record of diplocynodontines in Europe so far. An allegedly freshwater cf. Diplocynodon sp. contributes a rare faunal element to the vertebrate assemblage of the Ikovo locality, otherwise dominated by resident or facultative marine taxa. The fossil record and historical paleobiogeography of crocodyliforms from the Paleocene and Eocene of Europe are reviewed. As it has been already known, the middle Eocene fauna of crocodyliforms proves to be taxonomically diverse and complex. Its constituent lineages geographically originated in Asia or North America (Diplocynodontinae, Asiatosuchus-like crocodyloids, Planocraniidae), North America (derived alligatorines), Africa (Tomistominae), and Gondwana (ziphodont mesoeucrocodylians Iberosuchus and Bergisuchus), with possible subsequent speciation in Europe. We propose a novel hypothesis of Asian origins of European diplocynodontines, which will be explicitly tested in future studies. The revealed similarities between crocodylians and turtles from the Ikovo locality and those from Western Europe support the presence of a single Pan-European biogeographical zone during the middle Eocene, distinct from that of Asia.
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Large Pleistocene reptile tracks and traces were described from the Cape south coast of South Africa in 2020, including âprobable swim tracesâ. These trace fossils were found on loose slabs and blocks of the Klein Brak Formation. Subsequently, another surface has become exposed on this coastline, also on a loose slab. It exhibits more definitive evidence of swim traces in epirelief, probably made by the Nile crocodile (Crocodylus niloticus) or water monitor (Varanus niloticus), although a chelonian origin cannot be excluded. Length of a possible crocodylian trackmaker was estimated from measurements of interdigital distance in the swim traces. These provide a compelling example of reptile swim traces from Africa.
Significance:
Pleistocene reptile swim traces have now been confidently confirmed from the Cape south coast of South Africa.
The findings complement the suite of recently identified large reptile tracks.
Trackmaker size can be estimated from the dimensions of reptile swim traces.
These are the first compelling non-dinosaurian reptile swim traces to be described from Africa.